Color Doppler Ultrasound Imaging Course
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Enhance your medical skills with our Doppler Ultrasound Course! Master blood flow assessment and vascular diagnosis with expert-led training, hands-on practice, and cutting-edge techniques. Enroll now to advance your career.
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Introduction
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Converts AA into epoxyeicosatrienoic acids (EETs), which regulate vascular tone.
5. Endocannabinoid Biosynthesis:
Derived from membrane phospholipids via enzymatic reactions.
Degraded by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
Physiological Roles of Lipid Autocoids
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Easy to lift the limbs.
Active movement can be performed easily with minimum friction.
Easier to maintain the position of limbs with slings and pulleys in the required position.
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Supporting ropes.
Pulleys.
Slings.
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Wooden cleat.
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---
II. Peptic Ulcer Disease (PUD)
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NSAIDs – Inhibit prostaglandin synthesis, compromising mucosal defense.
Smoking – Impairs mucosal healing.
Stress (critical illness) – Leads to stress ulcers.
Zollinger-Ellison Syndrome – Gastrinoma with excess acid secretion.
Corticosteroids, alcohol, and genetic predisposition are other contributors.
Pathophysiology
The balance between aggressive factors (acid, pepsin, H. pylori, NSAIDs) and defensive mechanisms (mucus, bicarbonate, blood flow, prostaglandins) determines mucosal integrity.
H. pylori causes chronic inflammation and epithelial damage. NSAIDs decrease prostaglandins, reducing mucosal blood flow and bicarbonate production.
---
III. Clinical Features of Peptic Ulcer
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Duodenal ulcers: Pain relieved by food, occurs 2–3 hours after meals.
Gastric ulcers: Pain worsens with food intake.
Nausea, bloating, early satiety
Complications:
Bleeding: Hematemesis, melena.
Perforation: Sudden severe abdominal pain.
Gastric outlet obstruction
Penetration into adjacent organs (e.g., pancreas)
---
IV. Diagnosis of Peptic Ulcer
Endoscopy: Gold standard for diagnosis and biopsy to rule out malignancy.
Rapid urease test, histology, urea breath test, stool antigen – for H. pylori.
Serologic testing (less preferred).
Barium study
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Introduction
Lipid autocoids, also known as eicosanoids and related lipid mediators, are bioactive molecules derived from polyunsaturated fatty acids (PUFAs). These molecules play crucial roles in inflammation, immunity, hemostasis, cardiovascular function, and various physiological and pathological processes. Unlike classical hormones, lipid autocoids act locally, exerting their effects at or near their site of synthesis.
This document provides an in-depth analysis of lipid autocoids, covering their biosynthesis, classification, physiological roles, and clinical significance.
Classification of Lipid Autocoids
Lipid autocoids are broadly classified into the following categories:
1. Eicosanoids (Derived from Arachidonic Acid)
Prostaglandins (PGs)
Thromboxanes (TXs)
Leukotrienes (LTs)
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2. Specialized Pro-resolving Mediators (SPMs)
Resolvins
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3. Endocannabinoids
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Biosynthesis of Lipid Autocoids
Lipid autocoids are derived from membrane phospholipids through enzymatic pathways:
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Converts AA into epoxyeicosatrienoic acids (EETs), which regulate vascular tone.
5. Endocannabinoid Biosynthesis:
Derived from membrane phospholipids via enzymatic reactions.
Degraded by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
Physiological Roles of Lipid Autocoids
1. Inflammation and Immune Response
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Leukotrienes mediate allergic responses and asthma.
Lipoxins and resolvins promote resolution of inflammation.
2. Cardiovascular System
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3. Pulmonary Function
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4. Renal Function
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6. Reproductive System
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. Introduction to Suspension therapy.pptxDr. Prashant Kaushik Contents: -Definition, Principle, Advantages, Suspension instruments, Procedure, Types of suspension, Techniques.
Definition: - It is defined as suspending a part of the body or whole body with the supported slings and pulleys. That is given to the patients to increase ROM, increase muscle power, and support body part. Suspension free the body from friction of material upon the body components may be resting and it permits free movements without resistance. Late Mrs. Guthrie Smith invented the suspension apparatus.
Principle: - It is working under three principle: -
Friction.
Pendulum.
Eliminating gravity.
(a) Friction: - It occurs during a particular surface move on another. It is the force, which restrict the movement of an object. If the surface are more smooth and slippery will have less friction, in that surface the movement will be more and will cause slippery. If the surface is hard or rough results in more friction and the movements are opposed by the friction force.
The same principle is used in the suspension which has less friction causes smooth and easy movements.
(b) Pendulum: - Pendulum is heavy material suspended by the weightless thread. The force is applied on the pendulum it results in to and fro movement.
One complete swing is called as Oscillation. The arc of movement of the pendulum forms a segment of base of the cone. In the human body the pendular motion occurs mainly in the shoulder joint and the hip joint, forward leg movement and the arm swing movement while walking. The simple muscular contraction is necessary to initiate the oscillation. The same mechanism is used in the suspension therapy to maintain the muscle property, increase the range of movement and strengthening the muscles.
(c) Eliminating Gravity Movement: - If the person has the muscle power 2 (gravity eliminated movement), can go for the suspension exercises.
The patients should have minimal muscle power of 2 to under go for suspension therapy exercise. If the muscle power is above 3, the patient can go for against the gravity exercise instead of suspension therapy exercise.
Advantages: - It reduces the burden for the therapist.
Easy to lift the limbs.
Active movement can be performed easily with minimum friction.
Easier to maintain the position of limbs with slings and pulleys in the required position.
Suspension instruments: -
Suspension frame.
Supporting ropes.
Pulleys.
Slings.
S-hook and dog clips.
Wooden cleat.
(a) Suspension Frame: - It is made up of stainless steel or plastic-coated steels. In the top and head end side presents the 5-centimeter metal mesh, and the remaining sides are kept open. The measurement of the frame is 1m or 2m width X 2m length X 2m height. In the middle of the frame 2m length X 1m width X 1m height couch is placed for the patient's accommodation.
(b)Supporting Ropes: - It is 1.5 meters length, and 3 ply hemp ropes are used for the suspension to avoid slipping.
Arts-In-Medicine cancer support presentation .pptx
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- Pulmonary Embolism.
- GI Bleeding.
- ATN.
- Shunt Patency.
- Brain Death.
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A BRIEF STUDY OF REGIONAL REPERTORY (3).pdfsadanandarya1 Regional repertories in homeopathy are specialized reference works that focus on specific parts or systems of the body, such as the eyes, skin, respiratory system, or digestive organs. Unlike general repertories, which cover a wide range of symptoms and modalities across the entire body, regional repertories offer a more in-depth and concentrated analysis of particular areas, allowing practitioners to narrow down remedies with greater precision.
This study aims to understand the role and relevance of regional repertories in clinical practice. It explores various examples such as "Repertory of the Eyes" by William Jefferson Guernsey, and "Repertory of the Head" by J.B. Garth Wilkinson, among others. These repertories serve as valuable tools in cases where the pathology is strongly localized, and where a detailed repertorial analysis of that specific region is needed.
The study also highlights the advantages and limitations of regional repertories. While they provide focused insight and can enhance remedy selection in specific cases, they may lack the broader context required in complex or multi-systemic conditions. Thus, they are most effective when used in conjunction with general repertories and thorough case-taking.
regional repertories play a significant role in enhancing the accuracy of homeopathic prescriptions, especially in localized diseases. Their study is essential for practitioners seeking to deepen their understanding and refine their skills in remedy selection.
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Good Automated Laboratory Practices (GALP) Standards, Compliance, and Impleme...Dr. Smita Kumbhar Good Automated Laboratory Practices (GALP) refers to a structured framework designed to ensure the reliability, accuracy, and integrity of data generated by automated laboratory systems. These practices encompass standard operating procedures (SOPs), regulatory compliance, software validation, and personnel training to maintain consistency in laboratory operations. GALP is essential for laboratories that rely on automation to process high volumes of data while ensuring regulatory adherence, particularly in pharmaceutical, biotechnology, and clinical research environments.
Principles of GALP
The fundamental principles of GALP include:
1. Data Integrity: Ensuring accurate, reliable, and tamper-proof data recording and analysis.
2. Regulatory Compliance: Adhering to national and international standards such as ISO, 21 CFR Part 11, and QCI guidelines.
3. Standardized Processes: Implementing well-defined SOPs to guide laboratory operations.
4. System Validation: Regularly verifying automated instruments and software for functionality and compliance.
5. Personnel Training: Ensuring that laboratory staff are adequately trained to operate automated systems efficiently and accurately.
6. Risk Management: Identifying and mitigating potential risks in automated workflows.
7. Continuous Improvement: Periodic reviews and updates to laboratory practices to incorporate technological advancements.
GALP Requirements
To implement GALP, laboratories must adhere to certain requirements:
1. Standardized Documentation: Maintaining comprehensive records of laboratory procedures and automation processes.
2. Software and Instrument Validation: Ensuring that all automated systems function as intended and comply with regulatory requirements.
3. Data Security Measures: Implementing encryption, access control, and audit trails for secure data management.
4. Regulatory Compliance: Aligning with relevant regulations such as 21 CFR Part 11, ISO standards, and QCI guidelines.
5. Personnel Competency: Conducting periodic training and assessments for laboratory staff.
6. Audit Readiness: Preparing for internal and external inspections by maintaining up-to-date documentation.
SOPs of GALP
Standard Operating Procedures (SOPs) form the backbone of GALP. These SOPs cover:
1. Instrument Calibration: Regular calibration and validation of automated instruments.
2. Data Entry and Management: Guidelines on recording, storing, and retrieving data in compliance with regulatory standards.
3. Sample Handling: Ensuring standardized procedures for sample collection, processing, and storage.
4. Software Usage and Maintenance: Guidelines on software validation, updates, and troubleshooting.
5. Audit Trail Management: Recording and reviewing all modifications made to electronic data.
6. Corrective and Preventive Actions (CAPA): Addressing non-compliance and implementing necessary improvements.
Training Documentation
A key aspect of GALP is personnel training, which includes:
1. Training Plans
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Topics Covered:
Internal and External Environment
Water Quality, Sources & Pollution
Waterborne Diseases & Purification Methods
Air Composition & Pollution Control
Noise Pollution & Prevention
Solid Waste Management Techniques
Excreta Disposal Methods
Occupational Health Hazards
Pharmaceutical Pollution & Solutions
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Peptic Ulcer Disease (PUD) and Gastroesophageal Reflux Disease (GERD) are distinct yet overlapping disorders of the gastrointestinal system, marked by significant morbidity worldwide. These conditions illustrate the consequence of a disturbed harmony between offensive gastric secretions and the protective barriers of the mucosa. From ancient remedies to modern-day proton pump inhibitors and eradication therapies, the treatment approaches to these disorders represent a triumph of translational medicine.
While PUD typically involves mucosal erosion in the stomach or proximal duodenum due to Helicobacter pylori infection or NSAID use, GERD arises from the reflux of gastric contents into the esophagus due to incompetent lower esophageal sphincter tone. Both conditions necessitate a thorough understanding of their etiopathogenesis for rational therapy and long-term management. This document explores the latest, evidence-based treatment paradigms, structured with clarity and clinical relevance.
---
II. Peptic Ulcer Disease (PUD)
Definition and Epidemiology
Peptic ulcers are breaks in the mucosal lining of the stomach or duodenum that penetrate the muscularis mucosa. Gastric ulcers typically occur on the lesser curvature of the stomach, while duodenal ulcers are found in the first part of the duodenum.
Globally, the prevalence of PUD has declined, largely due to H. pylori eradication, yet NSAID-related ulcers persist, especially among the elderly.
Etiology and Risk Factors
Helicobacter pylori infection – Present in ~90% of duodenal and 70% of gastric ulcers.
NSAIDs – Inhibit prostaglandin synthesis, compromising mucosal defense.
Smoking – Impairs mucosal healing.
Stress (critical illness) – Leads to stress ulcers.
Zollinger-Ellison Syndrome – Gastrinoma with excess acid secretion.
Corticosteroids, alcohol, and genetic predisposition are other contributors.
Pathophysiology
The balance between aggressive factors (acid, pepsin, H. pylori, NSAIDs) and defensive mechanisms (mucus, bicarbonate, blood flow, prostaglandins) determines mucosal integrity.
H. pylori causes chronic inflammation and epithelial damage. NSAIDs decrease prostaglandins, reducing mucosal blood flow and bicarbonate production.
---
III. Clinical Features of Peptic Ulcer
Epigastric pain: Most common symptom; burning or gnawing in nature.
Duodenal ulcers: Pain relieved by food, occurs 2–3 hours after meals.
Gastric ulcers: Pain worsens with food intake.
Nausea, bloating, early satiety
Complications:
Bleeding: Hematemesis, melena.
Perforation: Sudden severe abdominal pain.
Gastric outlet obstruction
Penetration into adjacent organs (e.g., pancreas)
---
IV. Diagnosis of Peptic Ulcer
Endoscopy: Gold standard for diagnosis and biopsy to rule out malignancy.
Rapid urease test, histology, urea breath test, stool antigen – for H. pylori.
Serologic testing (less preferred).
Barium study
Time-Limited Innovation for CLL Control: Changing the Treatment Story With Ev...
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Anti malarial agents of pharmacology by Darade K.K
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A New Era in Treating Advanced Ovarian Cancer: Practical Tips for Maximizing ...
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This presentation was uploaded with the author’s consent.
How to Leverage AI to Boost Employee Wellness - Lydia Di Francesco - SocialHR...
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Technology
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While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
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Age and Gender
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Race Affects Attitudes
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Color Doppler Ultrasound Imaging Course
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